Acalculous Cholecystitis Diagnosis

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Acute acalculous cholecystitis (AAC) is especially dangerous during a serious illness or following major surgery ( 1 ). The incidence of AAC appears to be increasing ( 2 ); it is likely that increased awareness and improved imaging studies are identifying more cases ( 3 ). The mortality rate remains about 30% because the diagnosis remains challenging, the affected patients are critically ill, and because the disease itself can progress rapidly because of a high incidence of gangrene (> 50%) and perforation (> 10%).