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A xanthoma (pl. xanthomas or xanthomata ) (condition: xanthomatosis ), from Greek, Modern ξανθός (xanthós) , meaning 'yellow', is a deposition of yellowish cholesterol -rich material that can appear anywhere in the body in various disease states. [2] They are cutaneous manifestations of lipidosis in which lipids accumulate in large foam cells within the skin. [2] They are associated with hyperlipidemias , both primary and secondary types.